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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients

《医学前沿（英文）》   页码 889-906 doi: 10.1007/s11684-023-0994-x

摘要： Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic landscape of Chinese PCNSLs. Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics and clinicopathologic features were also analyzed. Structural variations were identified in all patients with a mean of 349, which did not significantly influence prognosis. Copy loss occurred in all samples, while gains were detected in 77.9% of the samples. The high level of copy number variations was significantly associated with poor progression-free survival (PFS) and overall survival (OS). A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF1, and NRXN3) detected in ≥ 10% of the cases. CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS. A prognostic risk scoring system was also established for PCNSL, which included Karnofsky performance status and six mutated genes (BRD4, EBF1, BTG1, CCND3, STAG2, and TMSB4X). Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs, thereby enriching the present understanding of the genetic mechanisms of PCNSL.

关键词： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Temperature variation of concrete box girder bridge

Jian WANG, Zhi FANG,

《结构与土木工程前沿（英文）》 2009年 第3卷 第4期   页码 407-413 doi: 10.1007/s11709-009-0053-y

摘要： On the basis of theoretical analysis and measurement on site, the temperature gradients and its variation on concrete box girder bridges resulting from ambient temperature, solar radiation, and structural temperature fields were discussed. With the help of the heat transfer theory and finite element method (FEM), the heat flux of the surface of concrete box girder was carried out, and all the heat fluxes were described as the convection. The results were compared with that from field measurements, and a good correlation was found. It was revealed that the methods, the parameters, the boundary condition used in this paper were reasonable. Last, some conclusions were obtained, which could provide the basis for box girder design under solar radiation.

关键词： temperature     transfer     correlation     radiation     variation    

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Assessment of liver volume variation to evaluate liver function

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 421-427 doi: 10.1007/s11684-012-0223-5

摘要：

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patients, we explored the correlation between hepatic volume and severity of the hepatic diseases. The clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collected. Computed tomography-derived liver volume (CTLV) and body surface area (BSA) of normal controls were calculated to get a regression formula for standard liver volume (SLV) and BSA. Then CTLV and SLV of all patients were calculated and grouped by Child-Turcotte-Pugh classification for cirrhosis patients and assigned according to prognosis of ALF patients for further comparison. It turned out that the mean liver volume of the control group was 1 058±337 cm3. SLV was correlated with BSA according to the regression formula. The hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liver volume index (CTLV/SLV). Likewise, in the death group of ALF patients, the volume index was significantly lower than that of the survival group. Based on volumetric study, we proposed an ROC (receiver operating characteristic) analysis to predict the prognosis of ALF patients that CTLV/SLV<83.9% indicates a poor prognosis. In conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver function and progression of cirrhosis and ALF. It is also a very useful marker for predicting the prognosis of ALF.

关键词： liver volume variation     cirrhosis     acute liver failure (ALF)    

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arsenic trioxide on proliferation and apoptosis of U266 cells and its relationship with the expression variation

ZHAN Rong, YU Qinghong, HUANG Haobo

《医学前沿（英文）》 2008年 第2卷 第4期   页码 356-360 doi: 10.1007/s11684-008-0068-0

摘要： The aim of this article is to explore the effect of arsenic trioxide (AsO) on the proliferation and apoptosis of myeloma cell line U266 and its relationship with the expression variation of vascular endothelial growth factor (VEGF). The viability and apoptosis of U266 cells were observed by methylthiazolyl- tetrazolium (MTT) assay and terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL). The effect of AsO on the VEGF expression of U266 cells were tested by enzyme linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR) analysis. We found that AsO could significantly inhibit the growth of U266 cells, and the concentration for 50% growth inhibition (IC) was 2 ?mol/L. After treatment with 2, 5, 10 ?mol/L AsO for 36 hours, dose-dependent apoptosis of U266 cells was observed. After treatment with 2, 5, 10 ?mol/L AsO for 72 hours, a dose-dependent reduction of VEGF in the supernatant of U266 cells culture was found. As far as single cells are concerned, nevertheless, the expression of VEGF mRNA did not vary. So we draw the conclusion that AsO could induce the apoptosis of U266 cells and inhibit their proliferation, decrease the tumor load, and lead to the reduction of VEGF in the culture supernatant, but not change the expression of VEGF in single U266 cells.

关键词： VEGF expression     expression variation     culture supernatant     labeling     concentration    

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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

《医学前沿（英文）》 2022年 第16卷 第5期   页码 773-783 doi: 10.1007/s11684-021-0902-1

摘要： The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitors (ICIs) in China has not been quantified. This cross-sectional study was conducted to estimate the number of Chinese cancer patients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune checkpoint inhibitor clinical practice guideline of the Chinese Society of Clinical Oncology. A total of 11 ICIs were recommended for 17 cancer types. The estimated number of eligible patients annually was 1 290 156 (55.18%), which included 888 738 males (60.05%) and 400 468 females (46.67%). The estimated number of responders annually was 448 972 (19.20%), which included 309 023 males (20.88%) and 139 764 females (16.29%). Gastric cancer (n=291 000, 12.45%), non-small-cell lung cancer (n=289 629, 12.39%), and hepatocellular carcinoma (n=277 100, 11.85%) were the top three cancer types with the highest number of eligible patients. Non-small-cell lung cancer (n=180 022, 7.70%), hepatocellular carcinoma (n=75 648, 3.24%), and small-cell lung cancer (n=64 362, 2.75%) were the top three cancer types with the highest number of responders. In conclusion, ICIs provide considerable benefit in Chinese cancer patients under optimal estimation.

关键词： benefit     China     eligibility     immune checkpoint inhibitor     public health    

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Temporal variation of heavy metal pollution in urban stormwater runoff

Wen LI, Zhenyao SHEN, Tian TIAN, Ruimin LIU, Jiali QIU

《环境科学与工程前沿（英文）》 2012年 第6卷 第5期   页码 692-700 doi: 10.1007/s11783-012-0444-5

摘要： Stormwater runoff from three types of urban surfaces, a parking lot, a street, and a building roof, was monitored during four rainfall events that occurred in the one-year period from June 2009 to June 2010. The event mean concentrations (EMC) of dissolved copper (Cu), lead (Pb), zinc (Zn), manganese (Mn), and iron (Fe) exceeded China’s National Water Quality Standards for Surface Water. The degree of heavy metal contamination was related to the type of underlying surfaces. Additionally, the concentration of dissolved heavy metals peaked shortly after the runoff began and then declined sharply as a result of adequate flushing. First flush effects of varying degrees were also observed during all of the monitored rainfall events based on the first flush ratio ( ). Redundancy analysis revealed that four environmental variables (rainfall depth, intensity, antecedent dry weather period and type of underlying surface) had significant effects on the strengths of the first flush effects, accounting for 72.9% of the variation in the . Dissolved metals presented varying first flush effects on different underlying surfaces that occurred in the following relative order: parking lot>roof>road for low intensity and high runoff volume rainfall events; parking lot>road>roof for high intensity and low runoff volume events. The relative strength of the first flush for dissolved heavy metals was Fe, Mn>Cu, Zn>Pb.

关键词： urban stormwater     heavy metal pollution     temporal variation     event mean concentration     first flush effect     redundancy analysis    

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RESPONSE OF WHEAT COMPOSITE CROSS POPULATIONS TO DISEASE AND CLIMATE VARIATION OVER 13 GENERATIONS

《农业科学与工程前沿（英文）》 2021年 第8卷 第3期   页码 400-415 doi: 10.15302/J-FASE-2021394

摘要：

Since the F5 (2005), three winter wheat composite cross populations (CCPs) based on germplasm specifically suitable for low-input conditions were subjected to natural selection under organic and conventional management. In the F6, each CCP was divided into two parallel populations (12 CCPs in total) and maintained continuously until 2018. Commonly used modern cultivars with different disease susceptibilities were grown alongside to assess the agronomic performance of the CCPs. The organically managed CCPs were comparable in yield and foliar disease resistance to two continuously used reference cultivars, Achat and Capo. In contrast, under conventional management the cv. Capo outyielded the CCPs (Achat was not tested), highlighting the importance of parental cultivar choice for specific management systems. The CCPs were found to be moderately resistant to brown rust and even to the newly emerged stripe rust races prevalent in Europe since 2011. Differences between the CCPs were mainly due to parental genetic background and were significant in the first five generations, but were no longer so in the last five generations. In addition, these differences tended to vary depending on the experimental year and the environmental stresses present. In conclusion, the CCPs despite being derived from older cultivars are able to compete with more recently released reference cultivars under organic farming practices and represent a dynamic germplasm resource.

 

关键词： evolutionary breeding     heterogeneous crop population     management system    

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Identification of structural parameters and boundary conditions using a minimum number of measurement

Ali KARIMPOUR, Salam RAHMATALLA

《结构与土木工程前沿（英文）》 2020年 第14卷 第6期   页码 1331-1348 doi: 10.1007/s11709-020-0686-4

摘要： This article proposes a novel methodology that uses mathematical and numerical models of a structure to build a data set and determine crucial nodes that possess the highest sensitivity. Regression surfaces between the structural parameters and structural output features, represented by the natural frequencies of the structure and local transmissibility, are built using the numerical data set. A description of a possible experimental application is provided, where sensors are mounted at crucial nodes, and the natural frequencies and local transmissibility at each natural frequency are determined from the power spectral density and the power spectral density ratios of the sensor responses, respectively. An inverse iterative process is then applied to identify the structural parameters by matching the experimental features with the available parameters in the myriad numerical data set. Three examples are presented to demonstrate the feasibility and efficacy of the proposed methodology. The results reveal that the method was able to accurately identify the boundary coefficients and physical parameters of the Euler-Bernoulli beam as well as a highway bridge model with elastic foundations using only two measurement points. It is expected that the proposed method will have practical applications in the identification and analysis of restored structural systems with unknown parameters and boundary coefficients.

关键词： structural model validation     eigenvalue problem     response surface     inverse problems    

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Erratum to: Meter-scale variation within a single transect demands attention to taxon accumulation curves

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-022-1560-5

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Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

《环境科学与工程前沿（英文）》 2011年 第5卷 第2期   页码 277-282 doi: 10.1007/s11783-010-0226-x

摘要： Sequencing batch reactor (SBR) for enhanced biological phosphorus removal (EBPR) processes was used to investigate the impact of the temperature shock on the competition between phosphorus-accumulating organisms (PAOs) and glycogen accumulating organisms (GAOs) in start-up stage. During the 34 days operation, SBR was set with temperature variation(0–5 d, 22±1°C; 6–13 d, 29±1°C; 14–34 d, 14±1°C). PAOs and GAOs were analyzed by fluorescent in situ hybridization (FISH), and intracellular polyphosphate granules were stained by Neisser-stain. The results showed that the influence of temperature shock on PAOs’ abundance was more serious than that on GAOs in the enriching process. Under sudden and substantially temperature variation, from 22±1°C to 29±1°C and then to 14±1°C, the domination of PAOs was deteriorated. After temperature shock, PAOs’ competitive advantages at low temperature that concluded in other study did not appear in our study. As mesophilic, GAOs (indicated by and ) were more temperature adaptive and better grew and took the domination at 14±1°C in the end. In the competition process, organisms of tetrad forming organisms (TFOs)-like shape which were considered as typical GAOs, were observed. With the evidence of poly-P granules containing by Neisser-straining and result of FISH, these organisms of TFOs-like shape were better to be assumed as adaption state or a special self-protecting shape of PAOs.

关键词： fluorescent in situ hybridization (FISH)     tetrad forming organisms (TFOs)     temperature variation     enhanced biological phosphorus removal (EBPR)    

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Multi-stage dual replica bit-line delay technique for process-variation-robust timing of lowvoltageSRAMsense

Shou-biao TAN,Wen-juan LU,Chun-yu PENG,Zheng-ping LI,You-wu TAO,Jun-ning CHEN

《信息与电子工程前沿（英文）》 2015年 第16卷 第8期   页码 700-706 doi: 10.1631/FITEE.1400439

摘要： A multi-stage dual replica bit-line delay (MDRBD) technique is proposed for reducing access time by suppressing the sense-amplifier enable (SAE) timing variation of low voltage static random-access memory (SRAM) applications. Compared with the traditional technique, this strategy, using statistical theory, reduces the timing variation by using multi-stage ideas, meanwhile doubling the replica bit-line (RBL) capacitance and discharge path simultaneously in each stage. At a supply voltage of 0.6 V, the simulation results show that the standard deviations of the SAE timing and cycle time with the proposed technique are 69.2% and 47.2%, respectively, smaller than that with a conventional RBL delay technique in TSMC 65 nm CMOS technology (Taiwan Semiconductor Manufacturing Company, Taiwan).

关键词： Process-variation-robust     Sense amplifier (SA)     Replica bit-line (RBL) delay     Timing variation    

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SPATIOTEMPORAL VARIATION OF WATER QUALITY AND ALGAL BIOMASS IN ERHAI LAKE AND ITS ENVIRONMENTAL MANAGEMENT

《农业科学与工程前沿（英文）》 2023年 第10卷 第4期   页码 566-578 doi: 10.15302/J-FASE-2023520

摘要：

Elucidating the spatiotemporal pattern of water quality and algal biomass is crucial for accurately tracing pollution sources and reducing the risk of algal blooms in lake systems. This study analyzed the spatiotemporal variability of water quality and algal biomass in Erhai Lake from 1994 to 2021 using water quality index (WQI), Mann-Kendall test and Sen’s slope combined methods. The potential causes of water quality deterioration and algal biomass dynamics were also elucidated. The results showed that the historical changes in the water environment of Erhai Lake mainly had three stages: satisfactory (1994‒2001), deteriorating (2002‒2010) and improving (2011‒2021). The changes in water quality and algal biomass were primarily affected by total nitrogen, total phosphorus and chemical oxygen demand in different stages. The water environment of Erhai Lake is currently improving significantly, starting in the southern area that is furthest from the sources of agricultural pollution, especially in summer and autumn. This is attributed to the implementation of control measures resulting in lower pollutant loads at particular times and places. Therefore, it is necessary to continue to promote standardized livestock farming, to strengthen rural wastewater collection and to investigate measures such as the interruption of the endogenous cycle.

关键词： Erhai Lake     control measures     water environment     water quality index (WQI)    

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Seasonal variation of nitrogen and phosphorus in Xiaojiang River—A tributary of the Three Gorges Reservoir

Zhe LI , Jinsong GUO , Man LONG , Fang FANG , Jinping SHENG , Hong ZHOU ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 334-340 doi: 10.1007/s11783-009-0039-y

摘要： A yearlong monitoring program in the backwater area of Xiaojiang River (XBA) was launched in order to investigate the eutrophication of backwater areas in tributaries of the Yangtze River in the Three Gorges Reservoir (TGR) in China, starting after the impoundment water level of the TGR reached 156 m. From March 2007 to March 2008, the average concentration of total nitrogen (TN) and total phosphorus (TP) were (1553 ± 484) μg·L and (62 ± 31) μg·L, respectively. The mean value of chlorophyll was (9.07 ± 0.91) μg·L. The trophic level of XBA was meso-eutrophic, while the general nutrient limitation was phosphorus. The results indicated that XBA has a strong ability to purify itself and has non-point source pollution from terrestrial runoff. The variation of TN/TP ratio was caused by a variation in TN rather than in TP when TN/TP<22. N-fixation from cyanobacteria occurred and became an important process in overcoming the nitrogen deficit under a low TN/TP ratio. When TN/TP ≥ 22, the variation of TP affected the TN/TP ratio more significantly than TN. The increase of TP in XBA was caused mainly by particulate phosphorus, which could originate from a non-point source as adsorptive inorganic forms after heavy rainfall and surface runoff. An increase in the river’s flow could also contribute to an unstable environment for the growth of phytoplankton.

关键词： Three Gorges Reservoir     eutrophication     nitrogen     phosphorus     seasonal variation     chlorophyll    

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.

关键词： PM2.5     Health effects     Integrated exposure-response model     Shijiazhuang    

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Forecast method for used number of parts and components based on complex network

LIU Fu-yun, QI Guo-ning, YANG Qing-hai

《机械工程前沿（英文）》 2006年 第1卷 第4期   页码 479-484 doi: 10.1007/s11465-006-0064-5

摘要： Applying directed complex network to model the main structure of a product family, according to in-degree bi-logarithmic coordinate distribution curve and distribution rule of nodes of the network, in-degree evolving rule of nodes of the network is presented and analytic expression of in-degree probability density of nodes is derived. Through the analysis of the relation between existing kinds of components and existing product numbers, an expression of the relation between kinds of components and product numbers is derived. A forecast method for the increment of component numbers and parts based on the increment of products is presented. As an example, the component numbers of an industrial steam turbine product family is forecasted, forecast result verified and forecast error analyzed.

关键词： complex network     industrial     component     analytic expression     forecast    

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标题 作者 时间 类型 操作

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients

期刊论文

Temperature variation of concrete box girder bridge

Jian WANG, Zhi FANG,

期刊论文

Assessment of liver volume variation to evaluate liver function

null

期刊论文

arsenic trioxide on proliferation and apoptosis of U266 cells and its relationship with the expression variation

ZHAN Rong, YU Qinghong, HUANG Haobo

期刊论文

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

期刊论文

Temporal variation of heavy metal pollution in urban stormwater runoff

Wen LI, Zhenyao SHEN, Tian TIAN, Ruimin LIU, Jiali QIU

期刊论文

RESPONSE OF WHEAT COMPOSITE CROSS POPULATIONS TO DISEASE AND CLIMATE VARIATION OVER 13 GENERATIONS

期刊论文

Identification of structural parameters and boundary conditions using a minimum number of measurement

Ali KARIMPOUR, Salam RAHMATALLA

期刊论文

Erratum to: Meter-scale variation within a single transect demands attention to taxon accumulation curves

期刊论文

Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

期刊论文

Multi-stage dual replica bit-line delay technique for process-variation-robust timing of lowvoltageSRAMsense

Shou-biao TAN,Wen-juan LU,Chun-yu PENG,Zheng-ping LI,You-wu TAO,Jun-ning CHEN

期刊论文

SPATIOTEMPORAL VARIATION OF WATER QUALITY AND ALGAL BIOMASS IN ERHAI LAKE AND ITS ENVIRONMENTAL MANAGEMENT

期刊论文

Seasonal variation of nitrogen and phosphorus in Xiaojiang River—A tributary of the Three Gorges Reservoir

Zhe LI , Jinsong GUO , Man LONG , Fang FANG , Jinping SHENG , Hong ZHOU ,

期刊论文

Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

期刊论文

Forecast method for used number of parts and components based on complex network

LIU Fu-yun, QI Guo-ning, YANG Qing-hai

期刊论文